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 COVID-19 specific T cell 관련 Pentamer 및 Tetramer 출시​​ 

■ MHC Class I Pentamer : detecting antigen-specific CD8+ T cells

■ MHC Class II Tetramer : track antigen-specific CD4+ T cells

List of catalog Pentamers & Tetramers 

DISEASE
ALLELE
CODE
PEPTIDE SEQUENCE
EPITOPE ORIGIN
COVID-19 / SARS-CoV-2
DRB1*04:01
4331B
QLIRAAEIRASANLAATK
SARS-CoV S protein (993-1010) (conserved in SARS-CoV-2)
COVID-19 / SARS-CoV-2
DRB1*04:01
4332
QALNTLVKQLSSNFGAI
SARS-CoV S protein (939-955)(conserved in SARS-CoV-2)
COVID-19 / SARS-CoV-2
DRB1*01:01
4331A
QLIRAAEIRASANLAATK
SARS-CoV S protein (993-1010) (conserved in SARS-CoV-2)
COVID-19 / SARS-CoV-2
DRB1*01:01
4330
MAYRFNGIGVTQNVLY
SARS-CoV S protein (884-899) (conserved in SARS-CoV-2)
COVID-19 / SARS-CoV-2
DRB1*01:01
4329
GAALQIPFAMQMAYRF
SARS-CoV S protein (873-888) (conserved in SARS-CoV-2)
COVID-19 / SARS-CoV-2
A*02:01
4326
VLNDILSRL
SARS-CoV Spike glycoprotein precursor (958-966) (conserved in SARS-CoV2)
COVID-19 / SARS-CoV-2
A*02:01
4324
NLNESLIDL
SARS-CoV Spike glycoprotein precursor (1174-1182) (conserved in SARS-CoV2)
COVID-19 / SARS-CoV-2
A*02:01
4323
LITGRLQSL
SARS-CoV Spike glycoprotein precursor (978-986) (conserved in SARS-CoV2)
COVID-19 / SARS-CoV-2
A*02:01
4322
ALNTLVKQL
SARS-CoV spike glycoprotein precursor (1202-1210) (conserved in SARS-CoV2)
COVID-19 / SARS-CoV-2
A*02:01
4321
FIAGLIAIV
SARS-CoV spike glycoprotein precursor (940-948) (conserved in SARS-CoV2)
COVID-19 / SARS-CoV-2
A*02:01
4320
LLLDRLNQL
SARS-CoV N protein 223-231 (conserved in SARS-CoV2)

List of Custom Pentamers & Tetramers 

HLA ALLELE
EPITOPE
PROTEIN
IEDB ID
NOTES
DRB1*04:01
QALNTLVKQLSSNFGAI
S
50311
also DRB1*01:01, *03:01, *07:01, *13:01
DRB1*04:01
QLIRAAEIRASANLAATK
S
100428
also DRB1*07:01, *15:01
DRB1*01:01
QLIRAAEIRASANLAATK
S
100428
also DRB1*07:01, *15:01
DRB1*01:01
MAYRFNGIGVTQNVLY
S
100300
also DRB1*04:01
DRB1*01:01
GAALQIPFAMQMAYRF
S
100048
also DRB1*03:01, *04:01, *13:01, *15:01
B*40:01
MEVTPSGTWL
N
190494
A*02:01
VVFLHVTYV
S
71663
A*02:01
VLNDILSRL
S
69657
A*02:01
RLNEVAKNL
S
54680
A*02:01
NLNESLIDL
S
44814
A*02:01
LITGRLQSL
S
36724
A*02:01
ALNTLVKQL
S
2801
A*02:01
FIAGLIAIV
S
16156
A*02:01
LLLDRLNQL
N
34743
A*02:01
LALLLLDRL
N
34851
A*02:01
ALNTPKDHI
N
2802
A*02:01
ILLNKHIDA
N
27182
A*02:01
GMSRIGMEV
N
21347