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COVID-19 specific T cell 관련 Pentamer 및 Tetramer 출시
■ MHC Class I Pentamer : detecting antigen-specific CD8+ T cells
■ MHC Class II Tetramer : track antigen-specific CD4+ T cells
List of catalog Pentamers & Tetramers
DISEASE | ALLELE | CODE | PEPTIDE SEQUENCE | EPITOPE ORIGIN |
|---|---|---|---|---|
COVID-19 / SARS-CoV-2 | DRB1*04:01 | 4331B | QLIRAAEIRASANLAATK | SARS-CoV S protein (993-1010) (conserved in SARS-CoV-2) |
COVID-19 / SARS-CoV-2 | DRB1*04:01 | 4332 | QALNTLVKQLSSNFGAI | SARS-CoV S protein (939-955)(conserved in SARS-CoV-2) |
COVID-19 / SARS-CoV-2 | DRB1*01:01 | 4331A | QLIRAAEIRASANLAATK | SARS-CoV S protein (993-1010) (conserved in SARS-CoV-2) |
COVID-19 / SARS-CoV-2 | DRB1*01:01 | 4330 | MAYRFNGIGVTQNVLY | SARS-CoV S protein (884-899) (conserved in SARS-CoV-2) |
COVID-19 / SARS-CoV-2 | DRB1*01:01 | 4329 | GAALQIPFAMQMAYRF | SARS-CoV S protein (873-888) (conserved in SARS-CoV-2) |
COVID-19 / SARS-CoV-2 | A*02:01 | 4326 | VLNDILSRL | SARS-CoV Spike glycoprotein precursor (958-966) (conserved in SARS-CoV2) |
COVID-19 / SARS-CoV-2 | A*02:01 | 4324 | NLNESLIDL | SARS-CoV Spike glycoprotein precursor (1174-1182) (conserved in SARS-CoV2) |
COVID-19 / SARS-CoV-2 | A*02:01 | 4323 | LITGRLQSL | SARS-CoV Spike glycoprotein precursor (978-986) (conserved in SARS-CoV2) |
COVID-19 / SARS-CoV-2 | A*02:01 | 4322 | ALNTLVKQL | SARS-CoV spike glycoprotein precursor (1202-1210) (conserved in SARS-CoV2) |
COVID-19 / SARS-CoV-2 | A*02:01 | 4321 | FIAGLIAIV | SARS-CoV spike glycoprotein precursor (940-948) (conserved in SARS-CoV2) |
COVID-19 / SARS-CoV-2 | A*02:01 | 4320 | LLLDRLNQL | SARS-CoV N protein 223-231 (conserved in SARS-CoV2) |
List of Custom Pentamers & Tetramers
HLA ALLELE | EPITOPE | PROTEIN | IEDB ID | NOTES |
|---|---|---|---|---|
DRB1*04:01 | QALNTLVKQLSSNFGAI | S | 50311 | also DRB1*01:01, *03:01, *07:01, *13:01 |
DRB1*04:01 | QLIRAAEIRASANLAATK | S | 100428 | also DRB1*07:01, *15:01 |
DRB1*01:01 | QLIRAAEIRASANLAATK | S | 100428 | also DRB1*07:01, *15:01 |
DRB1*01:01 | MAYRFNGIGVTQNVLY | S | 100300 | also DRB1*04:01 |
DRB1*01:01 | GAALQIPFAMQMAYRF | S | 100048 | also DRB1*03:01, *04:01, *13:01, *15:01 |
B*40:01 | MEVTPSGTWL | N | 190494 | |
A*02:01 | VVFLHVTYV | S | 71663 | |
A*02:01 | VLNDILSRL | S | 69657 | |
A*02:01 | RLNEVAKNL | S | 54680 | |
A*02:01 | NLNESLIDL | S | 44814 | |
A*02:01 | LITGRLQSL | S | 36724 | |
A*02:01 | ALNTLVKQL | S | 2801 | |
A*02:01 | FIAGLIAIV | S | 16156 | |
A*02:01 | LLLDRLNQL | N | 34743 | |
A*02:01 | LALLLLDRL | N | 34851 | |
A*02:01 | ALNTPKDHI | N | 2802 | |
A*02:01 | ILLNKHIDA | N | 27182 | |
A*02:01 | GMSRIGMEV | N | 21347 |
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