the future of life science,

make the better tomorrow with CellKor

Tools for SARS-CoV-2 Research 

The coronavirus, named for its coronal form, was first identified in the 1960s and can cause a range of respiratory symptoms. Coronavirus such as Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) can aggravate human symptoms and cause pneumonia, severe acute respiratory syndrome and death. SARS-CoV-2 (2019-nCoV) is the newly discovered coronavirus strain.

Chinese scientists have determined that novel coronavirus belongs to 2B CoV subgroup and is different from sars-cov. Genome sequencing showed that the sequence homology of SARS-CoV-2 and SARS-CoV was 79.5%, and that of SARS-CoV-2 and bat coronavirus was 96% [1].

Coronaviruses invade host cells by attaching spike proteins to specific host cell receptors. SARS-CoV uses the angiotensin-converting enzyme II(ACE2) host cell receptor, while MERS-CoV uses CD26(DPP4) [2]. Recent results indicate that SARS-CoV-2 can enter cells using the same receptor ACE2 as SARS-CoV [1.3.4]. More studies are needed to confirm ACE2 is the only way to infect the host for SARS-CoV-2. After SARS-CoV-2 enters the cell through ACE2, Cathepsin degrades Spike protein to release nucleic acid. Some studies have shown that using Cathepsin B/L inhibitors can block the process. The study also showed that SARS-CoV-2 could also be directly hydrolyzed by the transmembrane protein TMPRSS2, enter and release nucleic acids [5]。AI was used to screen the inhibitors (Baricitinib, Sunitinib, Erlotinib, etc.) of host endocytic regulatory factor AAK1, the inhibitors can block the delivery of virus to cells and the intracellular assembly of virus particles by inhibiting AAK1[6]。

FineTest® can provide a variety of tools for coronavirus (SARS-CoV-2) research, including human anti- SARS-CoV-2 antibody (IgG, IgM), inflammatory cytokines, to help the scientific community understand the mechanisms of infection and develop effective treatments.

SARS-CoV-2 specific antibodies, proteins and ELISA Kits 

References 

  1. Shi, Z.L., et al. Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin. bioRxiv 2020.

  2. Xintian Xu et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. SCIENCE CHINA Life Sciences.

  3. Xu, X., et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci. China Life Sci. 2020.

  4. Letko, M.C., Munster, V. Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV. bioRxiv 2020.

CellKor Inc.   I   주식회사 쎌코

대표이사 : 한규형  I  사업자등록번호 : 850-86-00807

(08389) 서울특별시 구로구 디지털로26길 5, 에이스하이엔드타워 1차 208

208, 5, Digital-ro 26-gil, Guro-gu, Seoul, Republic of Korea

Tel. 02.6951.5302  I  Fax. 02.6951.5307  I  info@cellkor.com

COPYRIGHT ⓒ 2017 CELLKOR INC. ALL RIGHTS RESERVED